Description

Endomorphin 2 Tfa is a synthetic peptide analog of the endogenous opioid peptide endomorphin-2, modified with a trifluoroacetate (Tfa) salt. This compound is of significant interest for its high affinity and selectivity for the μ-opioid receptor, making it a crucial tool for advanced neuroscience and pharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies investigating pain management pathways, opioid receptor function, and novel therapeutic agents.

Application

• Neuroscience Research: As a selective μ-opioid receptor agonist for studying receptor binding, signal transduction, and neural circuitry related to pain and reward.
• Pharmacological Studies: Used in vitro and in vivo to investigate analgesic effects, tolerance development, and the physiological roles of endogenous opioids.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the design and screening of new analgesic drugs with potentially improved efficacy and reduced side-effect profiles.
• Biochemical Assays: Employed in competitive binding assays, functional cell-based assays, and enzyme-linked immunosorbent assays (ELISAs) to quantify biological activity.
• Academic & Clinical Research: Supports fundamental research into the mechanisms of chronic pain, addiction, and stress-related disorders.

Basic Information

Item	Details
Product Name	Endomorphin 2 Tfa
CAS No.	1276124-00-5
Molecular Formula	C36H50N8O8 • C2HF3O2 (or similar, contact for exact salt form)
Molecular Weight	Contact for details
Synonyms	Endomorphin-2 Trifluoroacetate; H-Tyr-Pro-Phe-Phe-NH2 TFA; Tyr-Pro-Phe-Phe-NH2 • TFA; Endomorphin 2 (TFA); EM-2 TFA; Opioid Peptide Endomorphin-2 TFA Salt; μ-Opioid Receptor Agonist Peptide TFA; L-Tyrosyl-L-prolyl-L-phenylalanyl-L-phenylalaninamide trifluoroacetate
EINECS	Contact for details

Quality Control

Our Endomorphin 2 Tfa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and amino acid analysis. We provide a Certificate of Analysis (COA) with each shipment, detailing purity, content, and solvent residues to ensure compliance with research-grade standards. Custom synthesis and purification to specific requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.