Description

3-(Trifluoromethylsulfonyl)Benzaldehyde is a high-value, multi-functional aromatic aldehyde building block distinguished by its electron-withdrawing trifluoromethylsulfonyl substituent. This compound matters for its unique reactivity profile, enabling the synthesis of complex molecules with enhanced properties like metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethylsulfonyl group can improve bioactivity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in asymmetric catalysis and organometallic chemistry.
• Functional Material Precursor: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers requiring specific electronic and steric characteristics.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological mechanisms and target engagement.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	3-(Trifluoromethylsulfonyl)Benzaldehyde
CAS No.	1274904-33-4
Molecular Formula	C8H5F3O3S
Molecular Weight	238.18 g/mol
Synonyms	3-Formylbenzenesulfonyl fluoride, trifluoromethyl derivative; 3-(Trifluoromethanesulfonyl)benzaldehyde; m-(Trifluoromethylsulfonyl)benzaldehyde; Benzaldehyde, 3-[(trifluoromethyl)sulfonyl]-; α-Oxo-3-(trifluoromethylsulfonyl)benzenemethane; 3-(Triflyl)benzaldehyde; 3-Tf-Benzaldehyde
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethylsulfonyl)Benzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with relevant regulatory frameworks for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.