Description

5-Bromo-2-(1-Methylpiperidin-4-Yloxy)Pyrimidine is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrimidine core linked to a substituted piperidine moiety. This compound is of significant value for medicinal chemistry research and development, serving as a key building block for the synthesis of novel drug candidates. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing small molecule therapeutics, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: The bromopyrimidine structure makes it a valuable fragment for designing and synthesizing potential kinase inhibitors.
• Chemical Biology Probes: Employed in the creation of chemical probes to study biological pathways and target validation.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs performing bespoke organic synthesis for clients.

Basic Information

Product Name	5-Bromo-2-(1-Methylpiperidin-4-Yloxy)Pyrimidine
CAS No.	1274134-13-2
Molecular Formula	C10H14BrN3O
Molecular Weight	272.14 g/mol
Synonyms	5-Bromo-2-[(1-methyl-4-piperidinyl)oxy]pyrimidine; 2-[(1-Methylpiperidin-4-yl)oxy]-5-bromopyrimidine; 5-Bromo-2-(1-methylpiperidin-4-yloxy)pyrimidine; 5-Bromo-2-(N-methyl-4-piperidyloxy)pyrimidine; 1274134-13-2; 5-Br-2-(1-Me-piperidin-4-yloxy)-pyrimidine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(1-Methylpiperidin-4-Yloxy)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.