Description

(2R,3S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Hydroxybutanoic Acid Hydrate is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. Its primary value lies in serving as a critical Fmoc-protected building block for solid-phase peptide synthesis (SPPS), enabling the precise construction of complex peptides and proteins. This compound is indispensable for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on novel therapeutic agents and biochemical studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated, sequential assembly of peptide chains.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Acts as a key reagent for linking peptides to other molecules, such as proteins, dyes, or polymers, for diagnostic and therapeutic applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial Research: Essential for studying protein structure-function relationships, enzyme mechanisms, and signal transduction pathways.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Item	Detail
Product Name	(2R,3S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Hydroxybutanoic Acid Hydrate
CAS No.	1272755-74-4
Molecular Formula	C19H19NO6 · xH2O
Molecular Weight	357.36 g/mol (Anhydrous basis)
Synonyms	Fmoc-Thr-OH · H2O; Fmoc-L-threonine hydrate; Fmoc-Thr-OH hydrate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine hydrate; (2R,3S)-2-(((9H-Fluoren-9-ylmethoxy)carbonyl)amino)-3-hydroxybutanoic acid hydrate; Nα-Fmoc-L-threonine monohydrate; Fmoc-Thr-OH·H2O; N-Fmoc-L-threonine hydrate
EINECS	Contact for details

Quality Control

Our (2R,3S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Hydroxybutanoic Acid Hydrate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive applications like peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We support compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	4.0% - 7.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Solubility	Clear, colorless solution in DMF or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.