Description

Fmoc-(R)-3-Amino-(6-Phenyl)-5-Hexenoicacid CAS NO 1272755-58-4 is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a terminal phenyl-substituted alkene side chain. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the introduction of unique structural motifs. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CROs engaged in the development of novel therapeutic peptides, protein engineering, and chemical biology research.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key chiral amino acid component for the automated synthesis of custom peptides with specific structural features.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates targeting GPCRs, enzymes, and protein-protein interactions.
• Peptidomimetic Design: Used to create stable peptide analogs where the alkene group can serve as a bioisostere or be utilized for further chemical modification (e.g., cross-linking, cyclization).
• Chemical Biology Probes: Synthesis of labeled or tagged peptides for studying biological mechanisms and pathways.
• Combinatorial Chemistry Libraries: Generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic Research: Fundamental studies in organic synthesis, asymmetric synthesis, and peptide chemistry.

Basic Information

Product Name	Fmoc-(R)-3-Amino-(6-Phenyl)-5-Hexenoicacid
CAS No.	1272755-58-4
Molecular Formula	C27H25NO4
Molecular Weight	427.49 g/mol
Synonyms	Fmoc-(R)-3-Amino-6-phenyl-5-hexenoic acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-phenylhex-5-enoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-6-phenyl-5-hexenoic acid; Fmoc-D-3-Amino-(6-phenyl)-5-hexenoic acid; Fmoc-(R)-Aph(Hexenyl); Fmoc-D-Aph(6-Ph,5-Hexenyl)-OH; Fmoc-(R)-3-Aph(6-Ph,5-Hexenyl)-OH; Fmoc-(R)-3-Amino-5-hexenoic acid(6-Phenyl) derivative
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-(6-Phenyl)-5-Hexenoicacid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, and specific impurity profiles to support regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.