Description

Fmoc-D-Lys-Oall Hcl CAS NO 1272754-92-3 is a protected amino acid derivative, specifically the Fmoc (9-fluorenylmethoxycarbonyl) and OAll (allyl ester) protected form of D-lysine hydrochloride. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of peptides and peptidomimetics, enabling the precise incorporation of D-lysine residues. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on creating novel therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical R&D: For the development of peptide-based drugs, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Bioconjugation and Labeling: The orthogonal OAll protecting group allows for selective deprotection and functionalization, useful for attaching fluorophores, biotin, or other tags to the lysine side chain.
• Structural Biology Studies: Used to incorporate D-amino acids into peptides to study protein folding, stability, and enzyme resistance.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening of bioactive peptide leads.
• Production of Peptide Fragments: For the synthesis of specific fragments used in antibody production or as antigens.

Basic Information

Product Name	Fmoc-D-Lys-Oall Hcl
CAS No.	1272754-92-3
Molecular Formula	C30H30N2O5 • HCl
Molecular Weight	535.03 g/mol
Synonyms	Fmoc-D-lysine(OAll)-OH hydrochloride; N-α-Fmoc-N-ε-allyloxycarbonyl-D-lysine hydrochloride; Fmoc-D-Lys(Alloc)-OH • HCl; N6-(Allyloxycarbonyl)-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-lysine hydrochloride; (2R)-6-{[(Prop-2-en-1-yloxy)carbonyl]amino}-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride; Fmoc-D-Lys(Alloc)-OH hydrochloride; D-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-[(2-propen-1-yloxy)carbonyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our Fmoc-D-Lys-Oall Hcl is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, critical for sensitive peptide synthesis applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.