Description

Fmoc-2,6-Dimethyl-D-Phenylalanine is a non-natural, sterically hindered amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group, essential for modern solid-phase peptide synthesis (SPPS). This engineered building block is critical for introducing conformational constraints and enhancing the metabolic stability, potency, and selectivity of therapeutic peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based drugs, diagnostics, and biochemical tools.

Application

• Peptide Drug Discovery & Development: A key protected amino acid for the synthesis of peptide libraries and lead candidates with improved pharmacological profiles.
• Solid-Phase Peptide Synthesis (SPPS): Specifically designed for Fmoc-chemistry SPPS protocols to construct complex peptides containing hindered residues.
• Conformationally Restricted Peptides: Used to incorporate 2,6-dimethylphenylalanine side chains that impose specific backbone torsions, stabilizing secondary structures like helices or turns.
• GPCR-Targeting Peptides: Valuable in creating analogs for G-protein-coupled receptor research, where side-chain bulk can fine-tune receptor binding affinity and selectivity.
• Biochemical Probe Synthesis: Employed in the preparation of labeled or modified peptides used as tools for studying enzyme mechanisms or protein-protein interactions.
• Antimicrobial & Cell-Penetrating Peptides: Applied in the design of novel peptides where enhanced hydrophobicity and rigidity can improve membrane interaction and activity.

Basic Information

Product Name	Fmoc-2,6-Dimethyl-D-Phenylalanine
CAS No.	1270300-65-6
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-D-2,6-dimethylphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,6-dimethyl-D-phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-dimethylphenyl)propanoic acid; Fmoc-2,6-Dimethyl-D-Phe-OH; Fmoc-D-2,6-Dmp-OH; N-Fmoc-2,6-dimethyl-D-phenylalanine; Fmoc-D-(2,6-diMe)Phe
EINECS	Contact for details

Quality Control

Our Fmoc-2,6-Dimethyl-D-Phenylalanine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR/IR for structural confirmation. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.