Description

n-Fmoc-L-3-Ethoxy-Phenylalanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically designed to introduce the unique L-3-ethoxyphenylalanine residue into peptide chains, enabling the creation of peptides with tailored properties for advanced research and development. It is a critical building block for pharmaceutical researchers, medicinal chemists, and biotech companies developing novel peptide-based therapeutics, diagnostics, and biochemical tools. The Fmoc protecting group ensures compatibility with standard Fmoc-based SPPS protocols, offering reliable deprotection under mild basic conditions.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the automated synthesis of custom peptides.
• Pharmaceutical R&D: Incorporation into novel peptide drug candidates to modulate bioactivity, stability, and receptor binding affinity.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to explore the impact of the 3-ethoxy-phenyl side chain on peptide function.
• Bioconjugation: Serves as a precursor for creating peptide-based probes, labels, or linkers with specific aromatic character.
• Academic Research: Fundamental studies in biochemistry and chemical biology involving non-canonical amino acids.
• Peptide Library Production: Enables the generation of diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	n-Fmoc-L-3-Ethoxy-Phenylalanine
CAS No.	1270298-31-1
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-3-EtO-Phe-OH; Fmoc-L-3-Ethoxyphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-ethoxy-L-phenylalanine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(3-ethoxyphenyl)propanoic acid; N-α-Fmoc-3-ethoxy-L-phenylalanine; Fmoc-OEt-Phe-OH; Fmoc-3-Ethoxy-DL-phenylalanine (racemic mixture reference); BOC Sciences Brand Name: BBL-P-0756
EINECS	Contact for details

Quality Control

Our n-Fmoc-L-3-Ethoxy-Phenylalanine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, chemical purity, and residual solvent content. Our quality systems are designed to meet the rigorous standards expected in pharmaceutical and biotech supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.