Description

Fmoc-2,4,6-Trifluoro-L-Phenylalanine CAS NO 1270296-84-8 is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing a highly fluorinated aromatic side chain, which can significantly alter the physicochemical properties, metabolic stability, and binding affinity of target peptides. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biotech companies developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tert-butyl strategy, enabling the controlled assembly of complex peptide sequences.
• Pharmaceutical Research & Development: Used to synthesize peptide drug candidates where fluorination enhances bioavailability, target selectivity, and resistance to enzymatic degradation.
• Medicinal Chemistry & SAR Studies: Incorporates a unique trifluoromethylphenyl moiety to study structure-activity relationships and optimize peptide interactions with biological targets.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorinated peptide probes used in imaging, diagnostics, and biochemical assays.
• Peptidomimetics & Macrocyclic Peptides: Facilitates the construction of constrained or cyclic peptides with improved pharmacological profiles.
• Academic & Institutional Research: Employed in biochemistry and chemical biology laboratories for fundamental studies on protein folding, stability, and function.

Basic Information

Product Name	Fmoc-2,4,6-Trifluoro-L-Phenylalanine
CAS No.	1270296-84-8
Molecular Formula	C24H18F3NO4
Molecular Weight	441.40 g/mol
Synonyms	Fmoc-2,4,6-trifluoro-L-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,4,6-trifluoro-L-phenylalanine; Fmoc-L-2,4,6-Trifluorophenylalanine; Nα-Fmoc-2,4,6-trifluoro-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(2,4,6-trifluorophenyl)propanoic acid; Fmoc-TriF-Phe-OH; Fmoc-Phe(2,4,6-F3)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-2,4,6-Trifluoro-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation (IR, NMR, MS). Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.