Description

Fmoc-3,5-Dimethy-D-Phenylalanine is a protected, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing sterically hindered, hydrophobic motifs into peptide chains, enabling the research and development of novel bioactive molecules with enhanced stability and specificity. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biotech companies focused on peptide-based drug discovery, proteomics, and the synthesis of complex peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated, stepwise construction of custom peptides.
• Pharmaceutical Research & Development: Used to incorporate unique structural elements into peptide drug candidates to improve metabolic stability, receptor binding affinity, and bioavailability.
• Synthesis of Peptidomimetics: Serves as a precursor for creating non-peptide compounds that mimic the structure and function of natural peptides.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling of peptides with tags, dyes, or other functional groups for diagnostic and imaging applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic and Industrial Research: A fundamental reagent for studies in chemical biology, structural biology, and medicinal chemistry.

Basic Information

Item	Details
Product Name	Fmoc-3,5-Dimethy-D-Phenylalanine
CAS No.	1270290-76-0
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-D-3,5-dimethylphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,5-dimethyl-D-phenylalanine; Fmoc-3,5-Dimethyl-D-Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3,5-dimethylphenyl)propanoic acid; Fmoc-D-3,5-Dmp-OH; N-Fmoc-3,5-dimethyl-D-phenylalanine; Fmoc-D-3,5-Dimethylphenylalanine; Protected D-amino acid derivative
EINECS	Contact for details

Quality Control

Every batch of Fmoc-3,5-Dimethy-D-Phenylalanine is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and consistency to meet the exacting standards of peptide synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.