Description

n-Fmoc-3-Fluoro-L-Tyrosine CAS NO 1270290-56-6 is a protected, non-natural amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for introducing fluorinated tyrosine residues into peptide chains, enabling the study of protein-protein interactions, enzyme mechanisms, and the development of novel peptide-based therapeutics. It is an essential building block for pharmaceutical R&D, particularly in the creation of targeted drug candidates, diagnostic probes, and biochemical tools for academic and industrial laboratories.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the automated synthesis of fluorinated peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide drugs, including enzyme inhibitors and receptor agonists/antagonists.
• Chemical Biology & Proteomics: Enables site-specific fluorination of peptides for 19F NMR studies, bioconjugation, and probing protein structure-function relationships.
• Radiopharmaceutical Precursor: Serves as a precursor for synthesizing fluorinated peptides used in Positron Emission Tomography (PET) imaging agents.
• Bioconjugation & Labeling: Facilitates the creation of fluorinated peptide tags and linkers for antibody-drug conjugates (ADCs) and other bioconjugates.
• Academic Research: A vital reagent for studying tyrosine phosphorylation mimicry and modulating peptide stability and bioavailability.

Basic Information

Product Name	n-Fmoc-3-Fluoro-L-Tyrosine
CAS No.	1270290-56-6
Molecular Formula	C24H20FNO5
Molecular Weight	421.42 g/mol
Synonyms	Fmoc-3-F-Tyr-OH; Fmoc-3-Fluoro-L-tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-fluoro-L-tyrosine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(3-fluoro-4-hydroxyphenyl)propanoic acid; 3-Fluoro-L-tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-Fmoc-3'-fluoro-L-tyrosine; Fmoc-Tyr(3-F)-OH; Fmoc-3F-L-Tyrosine
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-Fluoro-L-Tyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide Certificates of Analysis (COA) with detailed specifications, ensuring the material meets the stringent requirements for pharmaceutical research and peptide synthesis. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.