Description

Cbz-2,6-Difluoro-D-Phenylalanine is a protected, non-natural amino acid derivative featuring a carboxybenzyl (Cbz) protecting group and fluorine substitutions at the 2- and 6-positions of the phenyl ring. This compound is a critical chiral building block in advanced pharmaceutical research and development, offering precise structural control for modulating the biological activity and metabolic stability of peptide-based therapeutics. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide-based drugs and protease inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms, which can enhance metabolic stability, bioavailability, and binding affinity.
• Peptide Synthesis: Serves as a protected D-configuration amino acid residue in solid-phase and solution-phase peptide synthesis (SPPS).
• API Development: Incorporated into the backbone of novel active pharmaceutical ingredients targeting various disease pathways.
• Bioconjugation: Potential use in creating labeled peptides or antibody-drug conjugates (ADCs) for diagnostic or therapeutic purposes.
• Chemical Biology Probes: Used to develop selective enzyme inhibitors or receptor ligands for biochemical research.

Basic Information

Product Name	Cbz-2,6-Difluoro-D-Phenylalanine
CAS No.	1270290-50-0
Molecular Formula	C₁₇H₁₅F₂NO₄
Molecular Weight	335.30 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-2,6-difluoro-D-phenylalanine; (R)-2-(((Benzyloxy)carbonyl)amino)-3-(2,6-difluorophenyl)propanoic acid; Z-2,6-Difluoro-D-Phe-OH; N-Cbz-2,6-Difluoro-D-Phenylalanine; Nα-Carbobenzoxy-2,6-difluoro-D-phenylalanine; (2R)-2-{[(Benzyloxy)carbonyl]amino}-3-(2,6-difluorophenyl)propanoic acid; 2,6-Difluoro-D-phenylalanine, N-carboxybenzyl derivative
EINECS	Contact for details

Quality Control

Our Cbz-2,6-Difluoro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.