Description

L-Phenylalanine, 4-Cyclohexyl- is a non-natural, cyclohexyl-substituted derivative of the essential amino acid L-phenylalanine. This modified amino acid is a valuable chiral building block in pharmaceutical research and development, particularly for the synthesis of novel peptides and peptidomimetics. It serves as a critical intermediate for medicinal chemists and researchers in the life sciences sector, enabling the exploration of new therapeutic agents with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in peptide-based drug discovery.
• Peptidomimetic Synthesis: Used to incorporate a hydrophobic cyclohexyl moiety into peptide backbones, creating analogs with improved pharmacological properties.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate enzyme specificity and inhibition mechanisms.
• Proteomics & Chemical Biology: Useful for the site-specific modification of peptides and proteins to study structure-activity relationships.
• Ligand Development: Serves as a precursor for designing novel ligands for receptors and enzymes in medicinal chemistry programs.

Basic Information

Product Name	L-Phenylalanine, 4-Cyclohexyl-
CAS No.	1269963-99-6
Molecular Formula	C15H21NO2
Molecular Weight	247.33 g/mol
Synonyms	(2S)-2-Amino-3-(4-cyclohexylphenyl)propanoic acid; 4-Cyclohexyl-L-phenylalanine; L-4-Cyclohexylphenylalanine; Fmoc-4-Cyclohexyl-L-phenylalanine (precursor form); p-Cyclohexyl-L-Phe; CHPA; Non-natural amino acid derivative
EINECS	Contact for details

Quality Control

Our L-Phenylalanine, 4-Cyclohexyl- is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.