Description

4-(3-Iodo-1-Isopropyl-1H-Pyrazol-4-Yl)Pyrimidin-2-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure containing iodine, pyrazole, and pyrimidine moieties. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel drug candidates, particularly in oncology and other disease areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Serves as a core structural component in the design and synthesis of potential kinase inhibitors due to its pyrimidine-amine pharmacophore.
• Chemical Biology Probes: Employed in the creation of chemical probes for studying specific biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Academic Research: Used in university and institutional laboratories for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	4-(3-Iodo-1-Isopropyl-1H-Pyrazol-4-Yl)Pyrimidin-2-Amine
CAS No.	1269440-54-1
Molecular Formula	C10H12IN5
Molecular Weight	329.14 g/mol
Synonyms	4-(3-Iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-amine; 2-Pyrimidinamine, 4-(3-iodo-1-(1-methylethyl)-1H-pyrazol-4-yl)-; 4-(3-Iodo-1-isopropyl-1H-pyrazol-4-yl)-2-pyrimidinamine; 4-(3-Iodo-1-propan-2-ylpyrazol-4-yl)pyrimidin-2-amine; CAS 1269440-54-1
EINECS	Contact for details

Quality Control

Every batch of 4-(3-Iodo-1-Isopropyl-1H-Pyrazol-4-Yl)Pyrimidin-2-Amine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with each shipment. We support development under various quality paradigms, including research-grade and cGMP for advanced clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.