Description

[1-(3,5-Difluorophenyl)Cyclopropyl]Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a unique constrained cyclopropylamine structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for CNS-targeting therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained cyclopropyl ring and difluorophenyl moiety.
• Protease Inhibitor Development: Serves as a precursor or core structure in the development of enzyme inhibitors.
• Agrochemical Synthesis: Potential intermediate for creating advanced crop protection agents with specific activity.
• Ligand Synthesis for Catalysis: Used in the preparation of specialized ligands for asymmetric synthesis and metal-catalyzed reactions.
• Bioconjugation & Probe Development: The amine hydrochloride group allows for conjugation in the development of biochemical probes and diagnostic agents.

Basic Information

Product Name	[1-(3,5-Difluorophenyl)Cyclopropyl]Amine Hydrochloride
CAS No.	1269188-75-1
Molecular Formula	C9H10ClF2N
Molecular Weight	205.63 g/mol
Synonyms	1-(3,5-Difluorophenyl)cyclopropanamine hydrochloride; 1-(3,5-Difluorophenyl)cyclopropylamine HCl; (1-(3,5-Difluorophenyl)cyclopropyl)amine hydrochloride; 3,5-Difluoro-1-cyclopropylbenzenamine hydrochloride; 1-Amino-1-(3,5-difluorophenyl)cyclopropane hydrochloride; Cyclopropanamine, 1-(3,5-difluorophenyl)-, hydrochloride; 1269188-75-1
EINECS	Contact for details

Quality Control

Our [1-(3,5-Difluorophenyl)Cyclopropyl]Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.