Description

R-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo- Methyl Ester is a high-purity, advanced pharmaceutical intermediate critical for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its precise molecular architecture, which serves as a key building block in modern medicinal chemistry. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development and scale-up of novel therapeutic agents, particularly within the anti-infective and specialty drug sectors.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel fluoroquinolone antibiotics and related therapeutic compounds.
• API Development: Used in research and development for constructing complex molecular frameworks in new drug candidates.
• Process Chemistry: Employed in route scouting, optimization, and scale-up activities within pharmaceutical manufacturing.
• Chemical Reference Standard: Acts as a high-purity standard for analytical method development, validation, and quality control testing.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for exploratory medicinal chemistry projects.
• Regulatory Filings: Supplied as a characterized material for inclusion in regulatory submission dossiers (e.g., DMF, CMC sections).

Basic Information

Product Name	R-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo- Methyl Ester
CAS No.	1268719-66-9
Molecular Formula	C20H23FN4O4
Molecular Weight	402.42 g/mol
Synonyms	9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid methyl ester; Garenoxacin intermediate; Garenoxacin methyl ester; AM-1155 intermediate; T-3811 intermediate; 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, methyl ester
EINECS	Contact for details

Quality Control

Our R-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo- Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications suitable for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and in original packaging until use to prevent degradation. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.