Description

3-Fluoro-4-Formylphenylacetylene is a high-value, multi-functional aromatic building block featuring both an aldehyde and an acetylene group on a fluorinated benzene ring. This unique structure makes it a critical intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and materials science industries for constructing novel compounds, including active pharmaceutical ingredients (APIs), liquid crystals, and organic electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and targeted therapy research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides with improved efficacy and selectivity.
• Material Science Precursor: Serves as a building block for organic semiconductors, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: The acetylene moiety is ideal for Sonogashira and other palladium-catalyzed cross-coupling reactions to form conjugated systems.
• Click Chemistry: The terminal alkyne group enables efficient Huisgen cycloaddition (click chemistry) for bioconjugation and polymer functionalization.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating molecular libraries.

Basic Information

Product Name	3-Fluoro-4-Formylphenylacetylene
CAS No.	1267502-64-6
Molecular Formula	C9H5FO
Molecular Weight	148.14 g/mol
Synonyms	4-Ethynyl-2-fluorobenzaldehyde; 2-Fluoro-4-ethynylbenzaldehyde; 4-Formyl-3-fluorophenylacetylene; 3-Fluoro-4-ethynylbenzaldehyde; 4-Ethynyl-3-fluorobenzaldehyde; 3-Fluoro-4-((trimethylsilyl)ethynyl)benzaldehyde (protected precursor); 2-Fluoro-4-(ethynyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Formylphenylacetylene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, well-ventilated place. Keep away from oxidizing agents and strong bases. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.