Description

4-Chloro-6-(Piperazin-1-Yl)-2-(Trifluoromethyl)Pyrimidine is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. Its core value lies in its unique molecular architecture, combining a reactive chloropyrimidine core with a piperazine moiety and a trifluoromethyl group, enabling precise modifications for creating novel compounds with targeted properties. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical sectors, where it serves as a key precursor for active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel small molecule drugs, particularly in oncology, central nervous system (CNS), and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrimidine and trifluoromethyl groups.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing chemical probes and inhibitors to study enzyme function and protein-protein interactions.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique electronic or surface properties.
• Contract Research & Development (CRO/CMO): Supplied to outsourcing partners for custom synthesis and process development projects.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and fluorine chemistry.

Basic Information

Product Name	4-Chloro-6-(Piperazin-1-Yl)-2-(Trifluoromethyl)Pyrimidine
CAS No.	1267062-78-1
Molecular Formula	C9H10ClF3N4
Molecular Weight	266.65 g/mol
Synonyms	4-Chloro-6-(piperazin-1-yl)-2-(trifluoromethyl)pyrimidine; 2-(Trifluoromethyl)-4-chloro-6-(1-piperazinyl)pyrimidine; 4-Chloro-6-piperazin-1-yl-2-trifluoromethylpyrimidine; 6-(Piperazin-1-yl)-4-chloro-2-(trifluoromethyl)pyrimidine; 1-[4-Chloro-2-(trifluoromethyl)pyrimidin-6-yl]piperazine; 4-Chloro-6-piperazinyl-2-(trifluoromethyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-(Piperazin-1-Yl)-2-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.