Description

4-Chloro-2-(5-Chloro-2-Fluorophenyl)-6,7-Dihydro-5H-Cyclopenta[D]Pyrimidine is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters because it provides a critical, structurally defined building block essential for research and development in modern medicinal chemistry, enabling the creation of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical producers focused on developing new drug candidates, particularly in oncology and other targeted therapy areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel small-molecule drug candidates.
• Kinase Inhibitor Synthesis: Serves as a core scaffold for the construction of potential kinase inhibitors, targeting various cancer pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• API Development: Employed in the pilot-scale and commercial-scale synthesis routes for advanced active pharmaceutical ingredients.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying specific biological targets and mechanisms.
• Custom Synthesis Building Block: Supplied to fine chemical companies for custom synthesis projects requiring this specific heterocyclic framework.

Basic Information

Product Name	4-Chloro-2-(5-Chloro-2-Fluorophenyl)-6,7-Dihydro-5H-Cyclopenta[D]Pyrimidine
CAS No.	1266522-90-0
Molecular Formula	C13H9Cl2FN2
Molecular Weight	295.13 g/mol
Synonyms	4-Chloro-2-(5-chloro-2-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine; 2-(5-Chloro-2-fluorophenyl)-4-chloro-5,6,7,8-tetrahydrocyclopenta[d]pyrimidine; 4-Chloro-2-(5-chloro-2-fluorophenyl)-5,6,7,8-tetrahydrocyclopenta[d]pyrimidine; 1266522-90-0; Cyclopenta[d]pyrimidine, 4-chloro-2-(5-chloro-2-fluorophenyl)-6,7-dihydro-5H-; 4-Chloro-2-(5-chloro-2-fluorophenyl)-5H-cyclopenta[d]pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(5-Chloro-2-Fluorophenyl)-6,7-Dihydro-5H-Cyclopenta[D]Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.