Description

(R)-1-(6-Chloro-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol CAS NO 1264038-82-5 is a high-purity chiral intermediate featuring a pyrimidine core substituted with a chloropyrimidinyl and a pyrrolidinol group. This compound matters as a critical building block in the synthesis of advanced pharmaceutical active ingredients, particularly for targeted therapies. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, including kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially in oncology and antiviral therapeutic areas.
• Kinase Inhibitor Synthesis: Serves as a crucial precursor for constructing complex molecules designed to modulate kinase activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Asymmetric Synthesis: Utilized in the preparation of enantiomerically pure compounds due to its defined (R)-configuration.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	(R)-1-(6-Chloro-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol
CAS No.	1264038-82-5
Molecular Formula	C9H10ClN3O
Molecular Weight	211.65 g/mol
Synonyms	(R)-1-(6-Chloropyrimidin-4-yl)pyrrolidin-3-ol; (3R)-1-(6-Chloro-4-pyrimidinyl)-3-pyrrolidinol; (R)-3-Pyrrolidinol, 1-(6-chloro-4-pyrimidinyl)-; 1-(6-Chloro-4-pyrimidinyl)-(3R)-pyrrolidin-3-ol; (R)-1-(6-Chloro-4-pyrimidinyl)pyrrolidin-3-ol; 1264038-82-5; (R)-1-(6-Chloro-pyrimidin-4-yl)-pyrrolidin-3-ol
EINECS	Contact for details

Quality Control

Our (R)-1-(6-Chloro-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to support your GMP-compliant research and development activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.