Description

Pyrrolo[2,1-F][1,2,4]Triazine-5-Carbonitrile, 4-Chloro- is a high-value heterocyclic building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, particularly in the development of novel kinase inhibitors and other targeted therapeutics. It is primarily required by research institutions and pharmaceutical companies engaged in medicinal chemistry, process R&D, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of potent kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Development: Serves as a critical raw material in the scale-up and commercial manufacturing of targeted small-molecule drugs.
• Chemical Biology: Employed in the design and synthesis of chemical probes to study biological pathways and protein function.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis and API production.

Basic Information

Item	Details
Product Name	Pyrrolo[2,1-F][1,2,4]Triazine-5-Carbonitrile, 4-Chloro-
CAS No.	1263286-52-7
Molecular Formula	C8H3ClN4
Molecular Weight	190.59 g/mol
Synonyms	4-Chloropyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile; 4-Chloro-7-azaindole-5-carbonitrile derivative; 4-Chloro-5-cyanopyrrolo[2,1-f][1,2,4]triazine; Pyrrolotriazine carbonitrile derivative; 1263286-52-7; 4-Chloro-pyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of Pyrrolo[2,1-F][1,2,4]Triazine-5-Carbonitrile, 4-Chloro- is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity, meeting the stringent requirements of pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.