Description

4-Cyclopropyl-2-Methanesulfonyl-6-Trifluoromethyl-Pyrimidine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyrimidine core functionalized with cyclopropyl, methanesulfonyl, and trifluoromethyl groups. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of agrochemicals and small-molecule therapeutics. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures. The specific structural motifs present in this intermediate offer unique reactivity and physicochemical properties essential for modern drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl and pyrimidine groups contribute to enhanced biological activity and environmental stability.
• Chemical Biology Probe Development: Serves as a core scaffold for creating tool compounds to study enzyme function and biological pathways in academic and industrial research settings.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and functional materials requiring specific electronic or steric properties.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of complex target molecules.

Basic Information

Product Name	4-Cyclopropyl-2-Methanesulfonyl-6-Trifluoromethyl-Pyrimidine
CAS No.	1263285-93-3
Molecular Formula	C9H9F3N2O2S
Molecular Weight	266.24 g/mol
Synonyms	4-Cyclopropyl-2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidine; 2-Methanesulfonyl-4-cyclopropyl-6-trifluoromethylpyrimidine; 6-(Trifluoromethyl)-4-cyclopropyl-2-(methylsulfonyl)pyrimidine; 4-Cyclopropyl-6-trifluoromethyl-2-methylsulfonylpyrimidine; 4-Cyclopropyl-2-(methylsulphonyl)-6-(trifluoromethyl)pyrimidine; 4-Cyclopropyl-2-methanesulfonyl-6-(trifluoromethyl)pyrimidine; CAS 1263285-93-3
EINECS	Contact for details

Quality Control

Our 4-Cyclopropyl-2-Methanesulfonyl-6-Trifluoromethyl-Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.