Description

tert-Butyl 3-((2-Chloropyrimidin-4-yl)methyl)piperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc group and a reactive 2-chloropyrimidine moiety. This compound is specifically engineered for the synthesis of complex active pharmaceutical ingredients (APIs) and bioactive molecules, offering a critical building block for medicinal chemistry and drug discovery programs. It is essential for research and development teams in the pharmaceutical, agrochemical, and fine chemical sectors seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted small-molecule drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile reactive sites.
• API Synthesis: Serves as a crucial building block in the multi-step production of complex Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target engagement.
• Agrochemical Development: Utilized as an intermediate in the research and synthesis of novel crop protection agents.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	tert-Butyl 3-((2-Chloropyrimidin-4-yl)methyl)piperidine-1-carboxylate
CAS No.	1263285-45-5
Molecular Formula	C15H20ClN3O2
Molecular Weight	309.79 g/mol
Synonyms	1-Boc-3-((2-chloropyrimidin-4-yl)methyl)piperidine; tert-Butyl 3-[(2-chloropyrimidin-4-yl)methyl]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-((2-chloropyrimidin-4-yl)methyl)piperidine; 3-((2-Chloro-4-pyrimidinyl)methyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1263285-45-5; Boc-3-((2-chloropyrimidin-4-yl)methyl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-((2-Chloropyrimidin-4-yl)methyl)piperidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.