Description

5-Chloro-2-Fluoro-4-Methylbenzenamine Hydrochloride is a high-purity, halogenated aniline derivative salt, serving as a critical building block in advanced organic synthesis. Its value lies in providing a functionalized aromatic amine core, essential for constructing complex molecules with specific electronic and steric properties. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the chloro-fluoro-methyl substitution pattern can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as a diazonium component for creating azo dyes and pigments with specific color fastness and light absorption properties.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for creating complex biaryl structures.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	5-Chloro-2-Fluoro-4-Methylbenzenamine Hydrochloride
CAS No.	1263274-31-2
Molecular Formula	C7H8Cl2FN
Molecular Weight	204.05 g/mol
Synonyms	5-Chloro-2-fluoro-4-methylaniline hydrochloride; 2-Fluoro-5-chloro-4-methylaniline hydrochloride; 4-Amino-2-chloro-5-fluorotoluene hydrochloride; 2-Chloro-4-amino-5-fluorotoluene hydrochloride; Benzenamine, 5-chloro-2-fluoro-4-methyl-, hydrochloride (1:1); 5-Chloro-2-fluoro-p-toluidine hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-4-Methylbenzenamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.