Description

(2-Amino-4-Fluorophenyl)Dimethylphosphine Oxide is a specialized organophosphorus compound featuring a unique aromatic amine-fluorine-phosphine oxide scaffold. This structure makes it a valuable key intermediate in advanced organic synthesis, particularly for constructing complex molecules with tailored electronic and steric properties. It is primarily sought by pharmaceutical researchers and agrochemical developers for the creation of novel active ingredients, ligands, and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing potential drug candidates, especially in kinase inhibitor and other targeted therapy research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its phosphine oxide moiety.
• Ligand Precursor: Serves as a starting material for synthesizing specialized phosphine-based ligands used in catalysis (e.g., cross-coupling reactions).
• Material Science Research: Employed in the development of advanced polymers, flame retardants, or electronic materials due to its aromatic and phosphorus-containing structure.
• Chemical Biology Probes: Useful for creating molecular probes to study biological processes involving phosphorylation or metal binding.

Basic Information

Item	Details
Product Name	(2-Amino-4-Fluorophenyl)Dimethylphosphine Oxide
CAS No.	1263180-81-9
Molecular Formula	C8H11FNOP
Molecular Weight	187.15 g/mol
Synonyms	Dimethyl(2-amino-4-fluorophenyl)phosphine oxide; (2-Amino-4-fluorophenyl)dimethylphosphine oxide; NSC 864005; 2-Amino-4-fluoro-N,N-dimethylbenzenaminium oxide; 4-Fluoro-2-aminophenyldimethylphosphine oxide
EINECS	Contact for details

Quality Control

Every batch of (2-Amino-4-Fluorophenyl)Dimethylphosphine Oxide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry to ensure identity and consistency. A Certificate of Analysis (COA) detailing all specifications is available with each shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.