Description

Boc-D-Dap(Dde)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced peptide synthesis. This compound is essential for researchers and manufacturers requiring precise control over side-chain reactivity during solid-phase and solution-phase peptide assembly. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of complex peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for introducing D-diaminopropionic acid residues with orthogonal protecting groups (Boc and Dde) for Fmoc-based strategies.
• Peptide Drug Discovery: Enables the construction of peptide libraries and novel peptide structures with specific modifications for activity screening and optimization.
• Conjugate Vaccine Development: Used in the synthesis of peptide antigens that require specific linkage points for carrier proteins.
• Bioconjugation and Labeling: The Dde protecting group allows for selective deprotection, facilitating site-specific attachment of fluorescent dyes, biotin, or other functional moieties.
• Research of Peptide Mimetics: Serves as a precursor for creating peptidomimetics and constrained peptides to improve metabolic stability and bioavailability.
• GPCR Ligand Synthesis: Applied in the production of peptide ligands for G-protein-coupled receptors, which are important drug targets.

Basic Information

Product Name	Boc-D-Dap(Dde)-Oh
CAS No.	1263047-33-1
Molecular Formula	C₂₁H₂₉N₃O₇
Molecular Weight	435.47 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-β-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)-D-diaminopropionic Acid; Boc-D-Dap(Dde)-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)amino)propanoic Acid; Boc-D-2,3-diaminopropionic acid(Dde); Boc-D-Dap(Dde); D-Dap(Boc, Dde)-OH
EINECS	Contact for details

Quality Control

Our Boc-D-Dap(Dde)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.