Description

Fmoc-D-Norarginine(Boc)2-Oh, (R)-n-α-(9-Fluorenylmethyloxycarbonyl)-N,n-Bis-T-Butyloxycarbonyl-2-Amino-4-Guanidino-Butyric Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring chirally pure building blocks with protected side-chain functionalities. It is primarily utilized in the pharmaceutical, biotechnology, and life science research sectors for developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of D-configured norarginine residues into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, particularly those targeting protein-protein interactions where arginine analogs are crucial.
• Peptidomimetic Design: Serves as a building block for creating modified peptides with enhanced stability, bioavailability, or specific biological activity.
• Combinatorial Chemistry Libraries: Employed to generate diverse arrays of peptides for high-throughput screening in drug discovery programs.
• Bioconjugation and Probe Development: The Fmoc protecting group allows for orthogonal deprotection strategies, useful in creating labeled peptides for diagnostic or imaging applications.
• Academic & Institutional Research: Fundamental tool for studying peptide structure, function, and synthesis methodologies in chemistry and biochemistry laboratories.

Basic Information

Item	Detail
Product Name	Fmoc-D-Norarginine(Boc)2-Oh
CAS No.	1263047-29-5
Molecular Formula	C32H42N4O8
Molecular Weight	610.70 g/mol
Synonyms	Fmoc-D-NorArg(Boc)2-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((bis((tert-butoxy)carbonyl)amino)(imino)methyl)amino)butanoic acid; Nα-Fmoc-Nω,Nω'-bis-Boc-D-norarginine; Fmoc-D-homoArg(Boc)2-OH; D-Fmoc-Norarginine(Boc)2; Fmoc-D-NorArg(Boc2)-OH; Protected D-Norarginine Fmoc derivative; (R)-Nα-(9-Fluorenylmethyloxycarbonyl)-Nω,Nω'-bis-tert-butyloxycarbonyl-2-amino-4-guanidinobutyric acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-Norarginine(Boc)2-Oh is manufactured under strict quality systems to ensure high chemical purity and batch-to-batch consistency, essential for sensitive peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity, purity, and chiral integrity. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.