Description

Dde-D-Dap(Fmoc)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers requiring precise control over side-chain reactivity, enabling the construction of complex peptides and bioconjugates. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on developing novel therapeutic peptides, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled, sequential assembly of peptides, particularly where selective deprotection is required.
• Orthogonal Protection Strategy: Enables the synthesis of complex peptides with multiple functional groups by allowing selective removal of the Dde (1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl) protecting group in the presence of Fmoc.
• Bioconjugation and Labeling: Used to introduce specific, reactive handles into peptides for subsequent coupling with fluorophores, drugs, or other biomolecules.
• Research & Development of Novel Therapeutics: Essential for medicinal chemists developing peptide-based drugs, including targeted cancer therapies and antimicrobial peptides.
• Combinatorial Chemistry Libraries: Serves as a valuable component in generating diverse peptide libraries for high-throughput screening against biological targets.

Basic Information

Product Name	Dde-D-Dap(Fmoc)-Oh
CAS No.	1263046-87-2
Molecular Formula	C₂₈H₃₃N₃O₇
Molecular Weight	523.58 g/mol
Synonyms	Fmoc-D-Dap(Dde)-OH; Nα-Fmoc-Nβ-Dde-D-2,3-diaminopropionic acid; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)amino)propanoic acid; D-Dap(Dde)-Fmoc; Fmoc-D-Dap(Dde)-OH; Nα-Fmoc-Nβ-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)-D-2,3-diaminopropanoic acid; D-2,3-Diaminopropionic Acid derivative (Fmoc/Dde)
EINECS	Contact for details

Quality Control

Our Dde-D-Dap(Fmoc)-Oh is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.