Description

Fmoc-L-β-Homo-Gln(Trt)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in constructing complex peptides and peptidomimetics, offering precise control over side-chain functionality during chain assembly. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled incorporation of a glutamine-like side chain with extended backbone (β-homo) structure into peptide sequences.
• Pharmaceutical Research: For the development of novel peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics with enhanced metabolic stability.
• Peptidomimetic Design: Enables the synthesis of non-natural peptide analogs (peptidomimetics) to explore structure-activity relationships and improve pharmacological properties.
• Bioconjugation & Probe Synthesis: Used in creating labeled peptides for diagnostic assays, imaging studies, and biochemical research tools.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to discover new bioactive molecules.
• Academic & Institutional Research: For fundamental studies in organic chemistry, medicinal chemistry, and chemical biology involving amino acid and peptide chemistry.

Basic Information

Product Name	Fmoc-L-β-Homo-Gln(Trt)-Oh
CAS No.	1263046-43-0
Molecular Formula	C45H44N2O5
Molecular Weight	692.85 g/mol
Synonyms	Fmoc-L-β-Homo-Gln(Trt)-OH; N-α-Fmoc-N-γ-trityl-L-β-homoglutamine; Fmoc-β-homo-Gln(Trt)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-oxo-5-((trityl)amino)pentanoic acid; Fmoc-L-β-homo-glutamine(Trt)-OH; Nα-Fmoc-Nγ-Trt-L-β-homoglutamine; Fmoc-βhGln(Trt)-OH; Fmoc-HomoGln(Trt)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homo-Gln(Trt)-Oh is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.