Description

Fmoc-D-Alg(Boc)2-Oh CAS NO 1263045-67-5 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled introduction of the non-proteinogenic amino acid D-2-Aminoadipic acid (D-Alg) into complex peptide chains, enabling advanced research in medicinal chemistry and drug discovery. It is an essential building block for pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of complex peptides containing D-2-Aminoadipic acid residues.
• Pharmaceutical Research: Used in the development and production of peptide drugs, hormone analogs, and targeted therapeutic agents.
• Medicinal Chemistry: Serves as a crucial building block for creating peptide libraries for structure-activity relationship (SAR) studies and high-throughput screening.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Academic & Institutional Research: Employed in biochemical and biophysical studies to investigate protein folding, stability, and function using engineered peptide sequences.
• Fine Chemical Manufacturing: A high-value intermediate for the custom synthesis of specialty peptides and chiral compounds on a commercial scale.

Basic Information

Product Name	Fmoc-D-Alg(Boc)2-Oh
CAS No.	1263045-67-5
Molecular Formula	C28H41NO8
Molecular Weight	519.63 g/mol
Synonyms	Fmoc-D-2-Aminoadipic acid bis(tert-butyl) ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-2-aminoadipic acid 1,6-bis(1,1-dimethylethyl) ester; Fmoc-D-Aad(Boc)2-OH; Fmoc-D-α-Aminoadipic acid bis(t-butyl) ester; N-Fmoc-D-2-aminoadipic acid di-tert-butyl ester; (2R)-2-[(9H-Fluoren-9-ylmethoxy)formamido]hexanedioic acid di-tert-butyl ester; D-2-Aminoadipic acid, N-Fmoc-, 1,6-di-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-D-Alg(Boc)2-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.