Description

Boc-Dab(Dde)-Oh CAS NO 1263045-50-6 is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for enabling complex, multi-step peptide assembly by providing selective deprotection strategies. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of complex peptide sequences, particularly those requiring branched or modified structures.
• Orthogonal Protection Strategy: The Dde (1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl) protecting group on the side-chain amine allows for selective removal in the presence of Boc (tert-butyloxycarbonyl) and other standard protecting groups, enabling sophisticated synthetic routes.
• Pharmaceutical Research: Used in the research and development of novel peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation and Labeling: Serves as a precursor for creating peptide conjugates with dyes, tags, or other molecules for diagnostic and imaging applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic and Industrial R&D: A fundamental reagent for universities and contract research organizations (CROs) exploring protein-protein interactions and peptide structure-activity relationships.

Basic Information

Product Name	Boc-Dab(Dde)-Oh
CAS No.	1263045-50-6
Molecular Formula	C₂₀H₃₁N₃O₇
Molecular Weight	425.48 g/mol
Synonyms	Nα-Boc-Nδ-Dde-L-α,γ-diaminobutyric acid; Boc-Dab(Dde)-OH; (S)-2-((tert-Butoxycarbonyl)amino)-4-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)amino)butanoic acid; Nδ-(1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl)-Nα-(tert-butoxycarbonyl)-L-2,4-diaminobutanoic acid; Boc-L-Dab(Dde)-OH; Boc-Dab(Dde); Fmoc-Dab(Dde)-OH precursor; Orthogonally protected Dab derivative.
EINECS	Contact for details

Quality Control

Our Boc-Dab(Dde)-Oh is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, essential for reproducible synthetic outcomes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) when not in use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.