Description

6-Fluoro-n-(4-(Trifluoromethyl)Phenethyl)Pyrido[2,3-D]Pyrimidin-4-Amine CAS NO 1262888-61-8 is a high-purity, advanced pharmaceutical intermediate belonging to the pyridopyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of novel, targeted therapeutic agents, particularly in oncology and kinase inhibitor research. It is essential for pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent kinase inhibitors for cancer therapy.
• Biochemical Research: Used as a reference standard and active scaffold in structure-activity relationship (SAR) studies for drug discovery programs.
• Preclinical Development: Serves as a crucial material for pharmacokinetic, pharmacodynamic, and toxicology studies during early drug candidate development.
• Custom Synthesis: Employed by fine chemical suppliers for the custom manufacturing of complex, fluorinated active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for exploring new chemical entities and their biological activities.

Basic Information

Product Name	6-Fluoro-n-(4-(Trifluoromethyl)Phenethyl)Pyrido[2,3-D]Pyrimidin-4-Amine
CAS No.	1262888-61-8
Molecular Formula	C₁₈H₁₄F₄N₄
Molecular Weight	362.33 g/mol
Synonyms	6-Fluoro-N-[2-[4-(trifluoromethyl)phenyl]ethyl]pyrido[2,3-d]pyrimidin-4-amine; 6-Fluoro-N-(4-(trifluoromethyl)phenethyl)pyrido[2,3-d]pyrimidin-4-amine; 1262888-61-8; 6-Fluoro-N-(2-(4-(trifluoromethyl)phenyl)ethyl)pyrido[2,3-d]pyrimidin-4-amine; Pyrido[2,3-d]pyrimidin-4-amine, 6-fluoro-N-[2-[4-(trifluoromethyl)phenyl]ethyl]-; 6-Fluoro-N-(4-trifluoromethylphenethyl)pyrido[2,3-d]pyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our 6-Fluoro-n-(4-(Trifluoromethyl)Phenethyl)Pyrido[2,3-D]Pyrimidin-4-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.