Description

(S)-n-Fmoc-2-(7'-Octenyl)Glycine is a non-natural, side-chain modified amino acid derivative featuring a terminal alkene group, protected at the N-terminus with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the site-specific incorporation of unique chemical handles for further bioconjugation or material functionalization. It is primarily utilized by researchers and manufacturers in pharmaceutical R&D, peptide therapeutics, and chemical biology for developing novel peptide-based drugs, probes, and biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of peptides containing alkene-functionalized side chains.
• Peptide Drug Discovery: Incorporation into therapeutic peptide sequences to introduce sites for click chemistry (e.g., thiol-ene) modifications with payloads like fluorescent tags, PEG chains, or cytotoxic agents.
• Chemical Biology Probes: Synthesis of activity-based probes or affinity tags to study protein function and interactions.
• Bioconjugation & Material Science: Functionalization of surfaces, polymers, or nanoparticles via the reactive alkene moiety to create peptide-hybrid materials.
• Structure-Activity Relationship (SAR) Studies: Used to explore the impact of hydrophobic, unsaturated side chains on peptide stability, membrane permeability, and biological activity.
• Library Synthesis: A key component in the generation of combinatorial peptide libraries for high-throughput screening.

Basic Information

Product Name	(S)-n-Fmoc-2-(7'-Octenyl)Glycine
CAS No.	1262886-64-5
Molecular Formula	C₂₆H₃₁NO₄
Molecular Weight	421.53 g/mol
Synonyms	Fmoc-(S)-2-(7-Octenyl)glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(7-octen-1-yl)-L-glycine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(7-octenyl)acetic acid; Fmoc-L-2-(7-Octenyl)Gly-OH; Fmoc-OctenylGly-OH; Nα-Fmoc-L-2-(7'-octenyl)glycine; N-Fmoc-L-2-(7-octenyl)glycine; (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oct-7-enoic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized by HPLC, NMR, and MS to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a cGMP-compliant quality management system to ensure traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.