Description

4'-Fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-ol is a high-value fluorinated biphenyl derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in the strategic incorporation of fluorine and trifluoromethyl groups, which are essential for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of drug candidates, particularly in areas like oncology, CNS disorders, and anti-inflammatory agents, where the fluorine moiety enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for improved lipophilicity and target binding.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and polymers where fluorinated aromatic units are required for thermal stability and specific electronic properties.
• Chemical Biology & Probe Development: Employed in creating fluorescent tags, molecular probes, and other tools for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	4'-Fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-ol
CAS No.	1261889-86-4
Molecular Formula	C14H8F4O
Molecular Weight	268.21 g/mol
Synonyms	3'-Trifluoromethyl-4'-fluorobiphenyl-3-ol; [1,1'-Biphenyl]-3-ol, 4'-fluoro-3'-(trifluoromethyl)-; 4'-Fluoro-3'-(trifluoromethyl)biphenyl-3-ol; 3-Hydroxy-4'-fluoro-3'-trifluoromethylbiphenyl; 4-Fluoro-3-trifluoromethylbiphenyl-3-ol; Biphenyl-3-ol, 4'-fluoro-3'-trifluoromethyl-
EINECS	Contact for details

Quality Control

Our 4'-Fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider under an inert atmosphere (e.g., nitrogen or argon). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.