Description

2',5'-Difluoro-[1,1'-Biphenyl]-3-Ol is a high-purity fluorinated biphenyl derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in the precise substitution pattern of fluorine and hydroxyl groups, which enables fine-tuning of electronic and steric properties in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorinated biphenyl core enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials in display and lighting technologies.
• Polymer Chemistry: Acts as a monomer or chain modifier for engineering plastics and high-performance polymers, imparting improved thermal and chemical resistance.
• Cross-Coupling Reactions: A versatile substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research: Valuable reference standard and starting material in academic and industrial R&D for exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	2',5'-Difluoro-[1,1'-Biphenyl]-3-Ol
CAS No.	1261889-63-7
Molecular Formula	C12H8F2O
Molecular Weight	206.19 g/mol
Synonyms	3-Hydroxy-2',5'-difluorobiphenyl; [1,1'-Biphenyl]-3-ol, 2',5'-difluoro-; 2',5'-Difluoro-3-hydroxybiphenyl; 2',5'-Difluoro-3-phenylphenol; 3-(2,5-Difluorophenyl)phenol; Biphenyl-3-ol, 2',5'-difluoro-
EINECS	Contact for details

Quality Control

Our 2',5'-Difluoro-[1,1'-Biphenyl]-3-Ol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.