Description

2-Chloro-5-(Difluoromethyl)Pyrimidine is a high-purity halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the difluoromethylpyrimidine moiety into their target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides.
• Material Science Research: Serves as a precursor for functionalized heterocyclic compounds used in organic electronics and ligand design.
• Cross-Coupling Reactions: An effective substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl systems.
• Nucleophilic Substitution: The chloro group is readily displaced by various nucleophiles (amines, alkoxides) for further functionalization.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthetic projects requiring this specific scaffold.

Basic Information

Product Name	2-Chloro-5-(Difluoromethyl)Pyrimidine
CAS No.	1261869-28-6
Molecular Formula	C5H3ClF2N2
Molecular Weight	164.54 g/mol
Synonyms	2-Chloro-5-(difluoromethyl)pyrimidine; 5-(Difluoromethyl)-2-chloropyrimidine; Pyrimidine, 2-chloro-5-(difluoromethyl)-; 2-Chloro-5-difluoromethylpyrimidine; 1261869-28-6; 2-Chloro-5-(difluoromethyl)pyrimidine (CAS 1261869-28-6); 2-Chloro-5-(difluoromethyl)pyrimidine, 97+%
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Difluoromethyl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.