Description

1-(2-Amino-4-Fluorophenyl)Ethan-1-One Hydrochloride is a high-purity organic salt and a key fluorinated aromatic building block in advanced chemical synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical sector where the fluorine atom and amine hydrochloride group are critical for modulating biological activity and physicochemical properties. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and material science who require reliable, high-quality synthetic intermediates.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced fluorinated pesticides and herbicides, where the fluorine atom enhances metabolic stability and bioactivity.
• Material Science Research: Serves as a precursor for specialty chemicals, including fluorinated liquid crystals, polymers, and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring novel organic reactions and creating libraries of fluorinated compounds for screening.
• Fine Chemical Production: Integral to custom synthesis and contract manufacturing of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	1-(2-Amino-4-Fluorophenyl)Ethan-1-One Hydrochloride
CAS No.	1261861-04-4
Molecular Formula	C8H9FNO•HCl
Molecular Weight	189.62 g/mol (Free base: 153.16 g/mol)
Synonyms	2'-Amino-4'-fluoroacetophenone hydrochloride; 1-(2-Amino-4-fluorophenyl)ethanone hydrochloride; 4'-Fluoro-2'-aminoacetophenone HCl; 2-Acetyl-5-fluoroaniline hydrochloride; 1-(2-Amino-4-fluorophenyl)ethan-1-one hydrochloride; 4-Fluoro-2-aminoacetophenone hydrochloride; 2-Amino-4-fluoroacetophenone hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2-Amino-4-Fluorophenyl)Ethan-1-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to guarantee supply consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and light-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and oxidation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Any individual impurity ≤0.5%; Total impurities ≤1.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.