Description

3-Hydroxy-5-(Trifluoromethoxy)Benzaldehyde is a high-value aromatic aldehyde building block distinguished by its trifluoromethoxy and phenolic hydroxyl substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical and agrochemical active ingredients, where its unique fluorine-containing moiety can enhance metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group contributes to efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic cores used in electronic display and lighting technologies.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific chemical resistance or altered surface properties.
• Organic Synthesis & Research: A versatile reagent for constructing complex heterocycles and fluorinated aromatic systems in academic and industrial R&D laboratories.

Basic Information

Product Name	3-Hydroxy-5-(Trifluoromethoxy)Benzaldehyde
CAS No.	1261852-80-5
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	5-(Trifluoromethoxy)salicylaldehyde; 3-Formyl-5-(trifluoromethoxy)phenol; 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde; Benzaldehyde, 3-hydroxy-5-(trifluoromethoxy)-; 5-Trifluoromethoxysalicylaldehyde; 3-Hydroxy-5-trifluoromethoxybenzaldehyde; 5-(Trifluoromethoxy)-2-hydroxybenzaldehyde
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-5-(Trifluoromethoxy)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider under an inert atmosphere such as nitrogen or argon. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.