Description

2-Chloro-4-Trifluoromethoxybenzyl Alcohol is a high-purity, multi-functional aromatic alcohol building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethoxy substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and inflammatory diseases.
• Agrochemical Synthesis: Serves as a versatile precursor in the manufacture of modern herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethoxy group.
• Liquid Crystal & OLED Materials: Used in the synthesis of advanced electronic materials, where its aromatic core and halogenated groups contribute to desired molecular alignment and electronic properties.
• Organic Ligand & Catalyst Development: Employed as a starting material for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	2-Chloro-4-Trifluoromethoxybenzyl Alcohol
CAS No.	1261822-74-5
Molecular Formula	C8H6ClF3O2
Molecular Weight	226.58 g/mol
Synonyms	(2-Chloro-4-(trifluoromethoxy)phenyl)methanol; 2-Chloro-α-(trifluoromethoxy)benzyl Alcohol; 1-(2-Chloro-4-(trifluoromethoxy)phenyl)methanol; α-(Trifluoromethoxy)-2-chlorobenzyl Alcohol; Benzyl alcohol, 2-chloro-4-(trifluoromethoxy)-; 2-Chloro-4-(trifluoromethoxy)benzenemethanol
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Trifluoromethoxybenzyl Alcohol is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade meets a typical purity specification of ≥97% (by HPLC), with detailed impurity profiling available. Certificates of Analysis (COA) documenting identity, purity, and related substances are provided with each shipment. We support custom synthesis to meet specific purity requirements, including pharmaceutical (GMP) or research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.