Description

5-Chloropyrimidine-4-Acetonitrile is a versatile and high-purity chemical intermediate of significant importance in advanced organic synthesis. Its core value lies in its reactive nitrile and chlorinated pyrimidine functionalities, which enable its use as a key building block for constructing complex heterocyclic compounds. This product is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it serves as a precursor for active ingredients and novel molecular entities.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or precursor for creating specialized polymers and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling reagents.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring functionalized pyrimidine scaffolds.
• Academic & Industrial R&D: Fundamental research into heterocyclic chemistry and the development of new synthetic methodologies.

Basic Information

Item	Detail
Product Name	5-Chloropyrimidine-4-Acetonitrile
CAS No.	1261737-95-4
Molecular Formula	C6H4ClN3
Molecular Weight	153.57 g/mol
Synonyms	4-(Chloromethyl)pyrimidine-5-carbonitrile; 5-Chloro-4-pyrimidineacetonitrile; (5-Chloropyrimidin-4-yl)acetonitrile; 4-(Cyanomethyl)-5-chloropyrimidine; 5-Chloro-4-(cyanomethyl)pyrimidine; 1261737-95-4; 5-Chloropyrimidine-4-acetic acid nitrile
EINECS	Contact for details

Quality Control

Every batch of 5-Chloropyrimidine-4-Acetonitrile is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring traceability and consistency for critical pharmaceutical and agrochemical uses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.