Description

4-Chloro-6-(Difluoromethyl)Pyrimidine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated and fluorinated structure enables precise molecular modifications. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce chlorine and difluoromethyl functional groups into complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing potential drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrimidine core.
• Material Science Research: Serves as a precursor for creating functionalized organic materials and ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specific halogenated pyrimidine scaffolds.
• Academic & Industrial R&D: Utilized in discovery chemistry for exploring new chemical entities and reaction pathways in heterocyclic chemistry.

Basic Information

Product Name	4-Chloro-6-(Difluoromethyl)Pyrimidine
CAS No.	1261737-05-6
Molecular Formula	C5H3ClF2N2
Molecular Weight	164.54 g/mol
Synonyms	6-(Difluoromethyl)-4-chloropyrimidine; 4-Chloro-6-difluoromethylpyrimidine; Pyrimidine, 4-chloro-6-(difluoromethyl)-; 4-Chloro-6-(difluoromethyl)pyrimidine; 1261737-05-6
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-(Difluoromethyl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for each shipment, ensuring traceability and compliance with your internal quality standards and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.