Description

4-Chloro-6-(Difluoromethoxy)Pyrimidine is a high-value, halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoromethoxy and chloro substituents enable precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the biological activity of the pyrimidine core.
• Material Science Research: Serves as a precursor for creating functionalized molecules used in organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule assembly.
• Academic & Industrial R&D: A valuable reagent for methodological studies in fluorination chemistry and heterocyclic compound formation.

Basic Information

Item	Details
Product Name	4-Chloro-6-(Difluoromethoxy)Pyrimidine
CAS No.	1261734-25-1
Molecular Formula	C5H3ClF2N2O
Molecular Weight	192.54 g/mol
Synonyms	4-Chloro-6-(difluoromethoxy)pyrimidine; 6-(Difluoromethoxy)-4-chloropyrimidine; 4-Chloro-6-difluoromethoxypyrimidine; Pyrimidine, 4-chloro-6-(difluoromethoxy)-; 1261734-25-1; 4-Chloro-6-(difluoromethoxy)pyrimidine (CAS 1261734-25-1)
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-(Difluoromethoxy)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. The material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.