Description

5-Iodo-2-(Trifluoromethyl)Benzyl Alcohol CAS NO 1261682-35-2 is a high-value, multi-functional aromatic building block characterized by its iodine and trifluoromethyl substituents. This compound is essential for facilitating advanced cross-coupling reactions and introducing fluorinated motifs, which are critical for modulating the physicochemical properties of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated and fluorinated aromatic systems for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the iodine atom allows for further functionalization and the CF3 group improves lipophilicity.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings, enabling rapid diversification of chemical libraries.
• Fluorine Chemistry: Provides a stable source of a benzyl alcohol group adjacent to a trifluoromethyl group, useful for studying fluorine's effects in medicinal and materials chemistry.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	5-Iodo-2-(Trifluoromethyl)Benzyl Alcohol
CAS No.	1261682-35-2
Molecular Formula	C8H6F3IO
Molecular Weight	302.04 g/mol
Synonyms	α-(Trifluoromethyl)-5-iodo-o-tolyl alcohol; (5-Iodo-2-(trifluoromethyl)phenyl)methanol; 2-(Trifluoromethyl)-5-iodobenzyl alcohol; 1-Iodo-4-(hydroxymethyl)-2-(trifluoromethyl)benzene; 5-Iodo-α,α,α-trifluoro-o-toluyl alcohol; 1261682-35-2; 5-Iodo-2-trifluoromethylbenzyl alcohol
EINECS	Contact for details

Quality Control

Every batch of 5-Iodo-2-(Trifluoromethyl)Benzyl Alcohol is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and GC analysis, to ensure compliance with exacting research and development standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to guarantee traceability and consistency for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.