Description

3-Iodo-4-(Trifluoromethyl)Aniline is a high-purity, multi-functional aromatic amine building block of significant interest in advanced chemical synthesis. Its molecular structure, featuring both an iodine substituent and a trifluoromethyl group, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a building block for synthesizing specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science: Employed in the research and production of advanced polymers, liquid crystals, and organic electronic materials due to its halogenated and fluorinated aromatic core.
• Dye & Pigment Chemistry: Acts as an intermediate for creating specialized dyes and pigments with unique color fastness and optical properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl structures.

Basic Information

Item	Details
Product Name	3-Iodo-4-(Trifluoromethyl)Aniline
CAS No.	1261622-18-7
Molecular Formula	C7H5F3IN
Molecular Weight	287.02 g/mol
Synonyms	3-Iodo-4-(trifluoromethyl)benzenamine; 4-Amino-2-iodobenzotrifluoride; 2-Iodo-α,α,α-trifluoro-p-toluidine; 3-Iodo-4-trifluoromethylaniline; 3-Iodo-α,α,α-trifluoro-p-toluidine; Benzenamine, 3-iodo-4-(trifluoromethyl)-; 4-Trifluoromethyl-3-iodoaniline
EINECS	Contact for details

Quality Control

Our 3-Iodo-4-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support custom synthesis and can tailor specifications to meet specific project needs, including compliance with relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be performed under subdued lighting or in amber glass containers when possible.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.