Description

2-Hydroxy-6-(Trifluoromethoxy)Benzaldehyde is a specialized aromatic aldehyde building block featuring both phenolic and trifluoromethoxy substituents. This compound matters for its unique molecular architecture, which combines the reactivity of a benzaldehyde with the enhanced lipophilicity and metabolic stability imparted by the trifluoromethoxy group. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by manufacturers of advanced materials and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery programs, particularly for targets requiring fluorinated motifs to modulate bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethoxy group can improve pesticidal activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for mesogenic compounds used in display technologies, leveraging its rigid, polarizable core.
• Organic Electronic Materials: Employed in the synthesis of organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Chemical Research & Development: A versatile building block for academic and industrial research into new organic reactions, catalysis, and material science.
• Coordination Chemistry Ligand: The phenolic oxygen and aldehyde group can act as donor sites for metal complexation, useful in catalysis and sensor development.

Basic Information

Product Name	2-Hydroxy-6-(Trifluoromethoxy)Benzaldehyde
CAS No.	1261500-70-2
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	6-(Trifluoromethoxy)salicylaldehyde; 2-Formyl-3-(trifluoromethoxy)phenol; Salicylaldehyde, 6-(trifluoromethoxy)-; 2-Hydroxy-6-trifluoromethoxybenzaldehyde; 6-Trifluoromethoxysalicylaldehyde; 2-Hydroxy-6-(trifluoromethoxy)benzaldehyde; 6-(Trifluoromethoxy)-2-hydroxybenzaldehyde; 2-Hydroxy-6-(trifluoromethoxy)benzenecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-6-(Trifluoromethoxy)Benzaldehyde is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.