Description

3-(Difluoromethoxy)-2-Fluoroaniline is a specialized fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity and electronic properties imparted by the difluoromethoxy and fluoro substituents, enabling the construction of complex molecular architectures. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorinated moiety enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic components in electronic materials, contributing to improved performance in display and lighting technologies.
• Polymer & Specialty Chemistry: Employed in the synthesis of fluorinated polymers, dyes, and pigments that require specific solubility and stability profiles.
• Cross-Coupling Reactions: The aniline functionality makes it a suitable substrate for Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions to form complex amines.

Basic Information

Product Name	3-(Difluoromethoxy)-2-Fluoroaniline
CAS No.	1261498-41-2
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	2-Fluoro-3-(difluoromethoxy)aniline; 2-Fluoro-3-(difluoromethoxy)benzenamine; 3-(Difluoromethoxy)-2-fluoro-benzenamine; 2-Fluoro-α,α-difluoroanisidine; 1-Amino-2-fluoro-3-(difluoromethoxy)benzene; Benzenamine, 2-fluoro-3-(difluoromethoxy)-; 1261498-41-2
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)-2-Fluoroaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.