Description

6-(Difluoromethoxy)-2-Naphthaldehyde is a specialized aromatic aldehyde building block distinguished by its difluoromethoxy substituent. This compound matters for its role as a key intermediate in the synthesis of advanced pharmaceutical and agrochemical agents, where the fluorine atoms can significantly influence biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for anti-inflammatory and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the difluoromethoxy group enhances lipophilicity and target binding.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced organic electronic materials, contributing to the core structure of charge-transport or emissive layers.
• Fluorinated Dye & Pigment Development: Employed in the research and production of fluorinated colorants with improved lightfastness and chemical resistance.
• Cross-Coupling Reactions: The aldehyde functional group makes it a suitable substrate for various palladium-catalyzed cross-coupling and condensation reactions.
• Academic & Contract Research: A valuable reagent for methodological studies in organic synthesis, particularly in fluorination chemistry and heterocycle formation.

Basic Information

Product Name	6-(Difluoromethoxy)-2-Naphthaldehyde
CAS No.	1261488-79-2
Molecular Formula	C₁₂H₈F₂O₂
Molecular Weight	222.19 g/mol
Synonyms	2-Naphthaldehyde, 6-(difluoromethoxy)-; 6-(Difluoromethoxy)naphthalene-2-carboxaldehyde; 2-Formyl-6-(difluoromethoxy)naphthalene; 6-Difluoromethoxy-2-naphthalenecarboxaldehyde; 6-Difluoromethoxy-2-naphthaldehyde; 2-Naphthalenecarboxaldehyde, 6-(difluoromethoxy)-; 1261488-79-2
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)-2-Naphthaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability, as the compound is easily oxidized. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.