Description

Methyl 7-Tosyl-7H-Pyrrolo[2,3-D]Pyrimidine-4-Carboxylate CAS NO 1261365-63-2 is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyrimidine class of heterocyclic compounds. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly kinase inhibitors. It is essential for research and development organizations, contract manufacturing organizations (CMOs), and pharmaceutical companies engaged in the discovery and production of targeted cancer therapies and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel kinase inhibitors and other targeted therapeutic agents.
• Oncology Drug Development: Serves as a core scaffold for constructing molecules that modulate specific signaling pathways involved in cancer cell proliferation.
• Biochemical Research: Used as a reference standard or a starting material in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Contract Synthesis: Supplied to CROs and CMOs for custom synthesis projects requiring high-fidelity, complex heterocyclic building blocks.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for potential drug candidates during clinical development phases.

Basic Information

Product Name	Methyl 7-Tosyl-7H-Pyrrolo[2,3-D]Pyrimidine-4-Carboxylate
CAS No.	1261365-63-2
Molecular Formula	C16H15N3O4S
Molecular Weight	345.37 g/mol
Synonyms	Methyl 7-(4-methylphenyl)sulfonyl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate; 7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid, 7-[(4-methylphenyl)sulfonyl]-, methyl ester; Methyl 7-(p-tolylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate; 7-Tosyl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester; CAS 1261365-63-2; Pyrrolopyrimidine Tosylate Ester Intermediate
EINECS	Contact for details

Quality Control

Every batch of Methyl 7-Tosyl-7H-Pyrrolo[2,3-D]Pyrimidine-4-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.