Description

Moc-D-Norleucine CAS NO 1261072-86-9 is a high-purity, non-natural amino acid derivative where the amine group is protected by a methoxycarbonyl (Moc) group. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and molecular structure. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for developing novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and antiviral therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-isomer of norleucine into peptide chains, enabling structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: Serves as a core component in the design and synthesis of peptide-based protease inhibitors due to its modified side chain and protected amine.
• Biochemical Research: Employed as a standard or reagent in biochemical assays and studies investigating enzyme-substrate interactions and protein folding.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening to discover new lead compounds with optimized biological activity.
• Academic Research: Used in university and institutional labs for fundamental research in organic chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	Moc-D-Norleucine
CAS No.	1261072-86-9
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	N-[(Methoxycarbonyl)-D-norleucine]; (R)-2-((Methoxycarbonyl)amino)hexanoic acid; D-2-[(Methoxycarbonyl)amino]caproic acid; D-Norleucine, N-carboxy-, methyl ester; N-Moc-D-Norleucine; Methyloxycarbonyl-D-norleucine; (R)-2-(Methoxycarbonylamino)hexanoic acid; Boc-D-Nle-OH (common alternate protection scheme reference)
EINECS	Contact for details

Quality Control

Our Moc-D-Norleucine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.