Description

2,5-Difluoro-4-Methylphenol is a fluorinated phenolic compound of significant interest in advanced organic synthesis. Its value lies in its unique substitution pattern, which makes it a versatile and valuable building block for creating complex molecules with tailored properties. This intermediate is primarily sought by R&D and production teams in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Acts as a monomer or functionalization agent to introduce fluorine and phenolic groups into polymer chains, altering thermal and chemical resistance.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex, polyfunctional aromatic systems.
• Research & Development: Utilized in academic and industrial labs for methodological studies and the discovery of new chemical entities with potential biological or material science applications.

Basic Information

Product Name	2,5-Difluoro-4-Methylphenol
CAS No.	1260892-16-7
Molecular Formula	C7H6F2O
Molecular Weight	144.12 g/mol
Synonyms	4-Methyl-2,5-difluorophenol; 2,5-Difluoro-p-cresol; 2,5-Difluoro-4-methylphenol; 4-Methyl-2,5-difluorobenzenol; Phenol, 2,5-difluoro-4-methyl-; 1-Hydroxy-2,5-difluoro-4-methylbenzene; 2,5-Difluoro-4-hydroxytoluene
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Methylphenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring material traceability and reliable performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.